ResultsĪ total of 503 patients were enrolled: 301 in group A, and 202 in group B. Secondary end points included the restoration of hemostasis and safety measures. The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the diluted thrombin time or ecarin clotting time. We performed a multicenter, prospective, open-label study to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant effect of dabigatran in patients who had uncontrolled bleeding (group A) or were about to undergo an urgent procedure (group B). Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community.

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Idarucizumab reversal